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3 Adenosyl-B12, on the other hand, is a cofactor for the enzyme converting methylmalonyl-CoA to succinyl-CoA, which is crucial for channelling fatty acids and amino acids into the Krebs cycle for energy production

This capability enables the development of drug combinations with synergistic effects, a strategy known as multi-drug targeted pharmacology. Studies have demonstrated that multi-target drugs can more effectively address complex diseases [12]

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