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In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]

One of the most common factors leading to COPD is a history of smoking, although other particulate matter exposures, chemical exposures, respiratory infections, chronic bronchitis, asthma, and genetic susceptibility can also affect incidence (Yoshida and Tuder, 2007