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Based on the evidence that heat-shock proteins (Hsps) can exert neuroprotective effects against oxidative stress-related injury and that nutritional antioxidants are able to upregulate Hsps in neurons, use of nutritional antioxidants such as carnitine/acetyl-L-carnitine has been advocated to counteract the oxidative stress-induced brain damage in Alzheimer's disease [67, 119]

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The majority of cases were female, comprising 60.6% and 75.36% of the total cases, respectively

Two of the compounds, Alpha-Hederin and Hederasaponin-C, showed strong inhibition of shown to be effective at protecting against oxidative damage as well as synthetic antioxidants like butylated hydroxyanisole and BHT