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Some participants reported nausea and diarrhea as the most common side effects, but those were generally mild and easily managed

Ochtrop, P

This is surprising given the growing body of evidence suggesting that these medications could play a pivotal role in enhancing health and longevity in seniors

Glutamine is degraded into ammonia in the intestine and kidneys, achieving its partial excretion.15 At the level of the brain, hyperammonemia conditions an increase in glutamine synthetase activity, and by exceeding the metabolic capacity of the astrocyte, conditions intracellular osmolarity alterations with later edema, cytolysis, and proinflammatory cytokine release