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In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)

Originally developed for treatment of Type 2 diabetes (T2D), many patients reported appetite and weight reductions, and utilization soon skyrocketed for people with and without T2D

The selection of a linker is a crucial step in the design process of a fusion protein, especially in preserving the biological activity of the domains

If youre hungry for more ideas, check out the three GLP1 cookbooks below - all packed with meal plans, macro breakdowns, and digestion-friendly options