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The activation of cAMP-PKA signaling in gut IELs can inhibit the phosphorylation of Zeta-chain-associated protein kinase-70 (ZAP-70), stopping the signal from TCR, resulting in the inhibition of the immunological response of T cells (Wong et al., 2022

7 Conclusion Various lines of evidence at the molecular level and in model systems provide a mechanistic basis for a number of observations at the physiological level, where thiamine supplementation alleviates gastrointestinal dysfunction, suggesting that insufficient levels of thiamine may underlie this dysfunction