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For GHK-Cu, where the cosmetic mechanism depends on copper ion delivery to fibroblast integrins that trigger TGF- signaling and collagen gene expression, that localized dermal concentration is the only variable that matters

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Practical Implementation for Research Applications For anti-aging and skin rejuvenation research protocols, implementation uses 1-2 mg daily subcutaneous injection with optional combination topical 0.5-1% GHK-Cu serum, running 8-12 week cycles with 4-6 week off periods, repeating cycles 2-3 times per year