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As a GLP-1 receptor agonist , semaglutide: Calms appetite and food noise It acts on appetite centers in the brain, increasing satiety and reducing cravings

Disease improvement was assessed by the psoriasis area severity index (PASI), epidermal thickness, histological changes (skin-homing chemokines CCL17, Th17, Tc17, T22, CD3 +, CD4 +/CD8 +, CLA), and quality of life (dermatology life quality index)

Potential Side Effects: Commonly reported side effects of GLP-1 receptor agonist medications include nausea, vomiting, diarrhea, constipation, abdominal pain, headache, fatigue, and injection-site reactions

Niacinamide 2% : Regulates melanin transfer, promotes collagen, and reduces moisture loss