doi: 10.1016/S0009-8981(99)00150-3
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Glutathione ( 3a ) also reacts with organic electrophiles ( R ), such as several reactive metabolites of environmental contaminants and pharmaceutical drugs, and with metal ions of thiophilic elements ( M ) to yield the corresponding glutathione thioethers ( 5a ), alkyl-cysteines ( 5b ) and mercapturic acids ( 5c )
Furthermore, histone acetylation was decreased by IDH1 inhibition in Xenopus egg extracts (Extended Data Fig