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ANGPTL4-deficient diabetic podocytes and tubules showed reduced inflammation, decreased mitochondrial component release, decreased c-GAS-STING sensing activation, and lower levels of proinflammatory cytokine expression, suggesting that ANGPTL4 deficiency can restore mitochondrial homeostasis and suppress diabetes-associated renal inflammation, both of which are critical phenotypes in DKD (Srivastava et al., 2024)

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Administer once weekly at any time of day, with or without meals