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The model was able to predict total and unbound VPA plasma concentrations, along with concentrations of VPA metabolites (VPAglucuronide, 2enVPA and 4enVPA) for both single and multiple dosing

In GOLDEN-3 and -4, patients, investigators, site staff, and the study sponsor were blinded to all treatments during the treatment period

In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation

Low ferritin is the most common bloodwork red-flag at month 2 of GLP-1