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Encouragingly, however, neither drug was associated with significant increases in psychiatric hospitalizations or overall psychiatric symptom scores, supporting further safety evaluation in future clinical trials in psychiatric populations

In the blood, once secreted from the pineal gland, melatonin is usually bound to albumin, metabolized to 6-hydroxymelatonin by cytochrome P-450 isoforms and conjugated, in the liver, to produce the principal urinary metabolite, 6-sulfatoxy-melatonin, which is finally eliminated through the kidney 14

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