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The rate and extent of weight loss achieved with Wegovy (around 15% mean weight loss in clinical trials, as noted in NICE TA875) means these metabolic shifts can be quite pronounced

They are secreted mainly in the stomach and the main effect was thought to increase insulin secretion from the pancreatic beta cell in response to glucose given by mouth (but not by intravenous since it bypasses the stomach)

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Results: Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures