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*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Most patients reach therapeutic benefit between 1.0 and 1.7 mg weekly, though some require doses up to 2.4 mg

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