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La chirurgia metabolica e la farmacoterapia avanzata non devono essere viste come alternative contrapposte, ma come strumenti complementari nellarmamentario terapeutico dellobesit, da utilizzare in modo personalizzato in base al profilo clinico, alle preferenze del paziente e alla risposta ai trattamenti

(And Why Its Not Just Weight Gain) Lipedema is a chronic condition affecting mainly women, characterized by (Cifarelli, 2025): Disproportionate fat accumulation (typically in the legs and sometimes arms) Inflammation and fibrosis Impaired microvascular and lymphatic circulation Resistance to traditional weight loss approaches Recent research shows that lipedema is not simply a fat storage issueit is a complex condition involving: Chronic inflammation Fibrosis (thickening and stiffening of tissue) Hormonal influences (especially estrogen signaling) Microvascular and lymphatic changes Metabolic dysfunction This helps explain why conventional approaches like calorie restriction or even bariatric surgery may fail to meaningfully change lipedema tissue (Viana et al., 2025)