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The FDA-approved Mylotarg (gemtuzumab ozogamicin) utilizes an acid-sensitive hydrazone linker to efficiently release the DNA-damaging agent calicheamicin within lysosomes, achieving precise targeting of leukemia cells

The combined antioxidant, antimicrobial, and immunomodulatory properties of CM-EVs suggest their potential as an innovative feed additive for future applications

Histopathologically, OA menisci exhibit surface fibrillation, collagen disorganization, hypocellularity, calcification, and formation of fibrocartilaginous metaplasia

SGLT-2 inhibitors reduce mortality in lower-risk patients, although absolute benefits are smaller