Furthermore, using anti-4-HNE antibodies during the immunohistochemical analysis, they observed a more excellent distribution in the layers where these oxidative processes were accentuated, particularly the superficial layers
A commonly referenced low-dose starting point is: Around 1 milligram per kilogram of body weight More broadly, discussions around methylene blue dosing often highlight a low-dose window, since the compound appears to follow a hormetic response where smaller amounts can behave differently from higher concentrations
However, for any study involving oral administration, long-term protocols, or situations where temperature control might be inconsistent, the extra investment in the arginate salt is, in our professional opinion, well worth it
J Formosan Med Assoc (2019) 118:S4254