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GLP-1 antagonists are a class of medications that mainly manage blood sugar levels in people with Type 2 diabetes

Somagutta MR, Jain M, Uday U, Pendyala SK, Mahadevaiah A, Mahmutaj G et al (2022) Novel antidiabetic medications in polycystic ovary syndrome

Its main actions include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release, which reduces hepatic glucose production Slowing gastric emptying, which moderates post-meal glucose spikes Promoting satiety through central nervous system pathways, thereby reducing appetite GIP is released by K-cells in the proximal small intestine and shares some functions with GLP-1, particularly in enhancing insulin secretion after meals

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