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2) is actor-centric

Adrian Boswood has speculated, in an October 2018 veterinary journal article, about the possibility that "some dogs without CHF might have inappropriately received diuretics." Perhaps it is because, before the EPIC Study, GPs could detect a mitral valve murmur and lung congestion just as easily as could any cardiologist, and so the GPs also knew when and what to prescribe to treat CHF in MVD-affected dogs

Egger M, Davey Smith G, Schneider M, Minder C