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The percentage of hemolysis was calculated using the following formula: Biocompatibility assay The major organs, including the heart, liver, spleen, lungs, and kidneys of the previous CIA mouse models, were harvested from the euthanized mice for further H&E staining and histology assay to evaluate the toxicity of MCMs, SP, and SP@M

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In the second step, GSSG is reduced via the thiol-disulfide interchange reaction (Rao and Reddy 2008

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