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Under the condition of stress reactions such as fever, infection, or increased metabolic stress, patients with methylmalonic acidemia may manifest symptoms of acute metabolic decompensation such as impaired level of consciousness, hypotonia complicated by hyperammonemic encephalopathy, respiratory distress, acidosis, etc

Lu Y, Sun J, Yang M, Xing Y, Zhu W, Zhu J, et al

One group, mapping to innate immunity and antiviral responses (Oas2, Oas3, Mx2, Irf7, Irf9, STAT1, il1b), required GSH for optimal induction

In Cbs , Gclc and Gpx4 loci, both NRF2 binding and 5hmC levels increased along with active histone codes after DMF treatment (Fig