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They don't share receptors, metabolic enzymes, or physiological targets

Importantly, during infection with various pathogens, the expression of MHC II is subject to modulation ( Plasmodium falciparum provide coverage ranging from 98.5% to 100% against the parasite and include all variants of malaria pathogens that evade the immune system ( 3.3 Immune effector molecules 3.3.1 Cytokines Avian erythrocytes demonstrate precise PAMP and PRR responses at the transcriptomic level and are capable of producing specific signaling molecules, such as cytokines, to initiate immune responses