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GFR decreases with age and renal disease, and is higher in men, pregnant women, and some disease states (eg, diabetes, obesity) (Rosner 2006

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Specifically, the integration of GOx-triggered H 2 O 2 self-supply, GSH depletion-amplified Fenton-like reactions, and DOX-mediated chemotherapy collaboratively improved the tumor microenvironment, exerting a crucial role in cancer eradication