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La mayora de los casos de exantema por inhibidores del RFCE desarrolla una toxicidad de grado 1 2, slo en el 13 % de los pacientes de grado 3 y, de forma destacable, no se ha comunicado ningn caso de toxicidad cutnea con compromiso vital26

Furthermore, vitamin D also showed significant inhibition of NF-B pathways (181), and a regulatory effect regarding cytokine production, thus it inhibits proinflammatory cytokines in SLE pathogenesis, including IFN-, IL-17, IL-23, IL-6, and TNF- (182184), while stimulating anti-inflammatory cytokine production like IL-10 and TGF- (185, 186)

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