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Many compounds that produce extraordinary results in preclinical models fail to replicate those outcomes in human clinical trials

The marketing claim that B12 "boosts metabolism" is technically true in the context of correcting a deficiency, since B12 is essential for energy metabolism, but only applies if you are actually deficient

Initial Loading Dose Recommendations The first step in treating vitamin B12 deficiency is a loading dose

For details (including the form, dose, and dosing regimen) see the What It Does section of our Vitamin K Supplements Review, which includes our Top Picks among vitamin K supplements