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PubMed Ghigo, E., Arvat, E., Gianotti, L., Imbimbo, B

In a Phase II study published in The New England Journal of Medicine, participants with obesity who received the highest dose of Retatritude (12 mg) experienced an average weight loss of 24.2% over 48 weeks

These symptoms reflect metabolic adjustment rather than true withdrawal, and they arise from rapid shifts in blood glucose patterns and neurotransmitter signaling

Oxidative stress: the core pathogenesis and mechanism of Alzheimer's disease