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Furthermore, the restored gut microbiota composition, particularly the enrichment of prevotella (a known butyrate producer), suggests a compelling mechanism for the ameliorated oxidative stress and potential enhancement of gut and BBB integrity [39]

An increase in iron content switches Fas from being an anti-apoptotic protein to being a pro-apoptotic protein, thereby activating the extrinsic apoptosis pathway and promoting necroptosis [91]

134 Aged mice show a decrease in the reconstitution capability of their hematopoietic stem cells (HSCs), correlating with an increase in DNA damage 135,136 and with an increase in the levels of senescence effectors, such as p16INK4a