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We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig

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Key Takeaway: Glutathione is the body's primary internal antioxidant, produced to protect cells from damage caused by toxins and daily environmental stress

In the future, we need to create an open, trustworthy, and ethically sound data-sharing system and to promote the development of explainable AI and physics-guided models to achieve the true implementation of AI-driven precision medicine in cancer