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For Fitzpatrick III-V skin, the anti-inflammatory mechanism of GHK-Cu is an active clinical advantage, reducing the inflammatory response that can lead to post-inflammatory hyperpigmentation in darker skin tones

Allosteric (off active site) activators were reported in the literature as early as the mid-2000s, but they had poor potency, poor pharmacokinetics, species-selective activity (human but not rodent), and none made it close to the clinic

They said that compounded medications could contain contaminants, or dosing could vary quite a bit from that of name-brand medications and potentially be less effective