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Abstract Background and Aims: Incretin-based therapies, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, are essential treatments in diabetes management due to their efficacy in glycemic control and the additional benefits of GLP-1 RAs, which include cardiovascular and renal protection

The key breakthrough came with the identification of the Growth Hormone Secretagogue Receptor (GHS-R1a) later shown to also be the receptor for ghrelin , the bodys hunger hormone

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The rapid resolution of symptoms prior to substantial weight loss supported a pharmacologic rather than metabolic effect