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Other safety areas under investigation include: Lean muscle mass preservation significant weight loss can result in loss of muscle tissue, and researchers are monitoring body composition changes Bone density a consideration with rapid weight loss in general Thyroid C-cell effects a class concern for GLP-1 receptor agonists, though clinical significance in humans remains uncertain [13] Pancreatitis and gallbladder disease signals observed across the incretin class are being monitored for retatrutide, though no established causal link has been confirmed for this agent specifically Dehydration and kidney function prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury