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In pyroptosis-focused research, a phase I trial investigated an autophagy inhibitor (which indirectly enhances pyroptosis by promoting gasdermin E [GSDME] activation) in combination with nivolumab/ipilimumab in 42 patients with metastatic melanoma (171, 172)

The definition of vitamin B12 deficiency varies with the assay used but generally includes serum cobalamin levels below 148 pmol/L plus symptoms, or elevated serum homocysteine, or increased methylmalonic acid (MMA) (74)