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Researchers investigating insulin resistance models or glucose homeostasis should account for this mechanistic layering when selecting between the two compounds

They used DPP4-targeted immune therapy by vaccines in a C57BL/6J mouse model and were able to show comparable effects like in treatments with gliptins regarding GLP-1 plasma levels and post-prandial glucose excursion and insulin sensitivity in HFD-fed mice

Wong CP, Song Y, Elias VD, Magnusson KR, Ho E

These signaling cascades enhance glucose-dependent insulin secretion, inhibit glucagon release, slow gastric emptying, and promote pancreatic -cell survival and proliferation