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In mouse models of E/I dysfunction, GABA_B receptor agonists like arbaclofen have been shown to restore aspects of the E/I balance, resulting in improved behavioral deficits ( Histopathologically, while GABA supplementation helped in preserving some aspects of hippocampal structure, significant neurodegeneration and reduced neuron density remained, particularly in the CA4 region, similar to what was observed in the PPA-treated group

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Despite these trends, access remains a major barrier, particularly for low-income individuals who are uninsured or underinsured, highlighting the need to bridge the gap of affordability in the future

Studies on Saccharomyces cerevisiae yeast cells (line D 7) revealed that ALA within the 1 nM10 M concentration range does not affect cells cytochrome P450 content [129]