The World Health Organization (WHO) subsequently reviewed kava's safety and concluded that moderate consumption of kava in its traditional form, as a water-based suspension of roots, presents an "acceptably low level of health risk"
This natural regulatory mechanism provides substantial protection against toxicity from dietary sources or standard supplementation
[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Kargutkar N., Sawant-Mulay M., Hariharan P., Chandrakala S., Nadkarni A
Mitochondrial dysfunction is characterized by various degrees of ultrastructural mitochondrial damage, abnormal morphologic changes, increased permeability of the outer and inner membranes, impaired mitochondrial -oxidation, respiratory chain activity reduction, ROS overproduction, ATP depletion, and oxidative stress-mediated deletions of mtDNA inducing apoptosis (Ramanathan et al