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Ex-4 also reverses endothelial cell aging in the mouse brain, which is characterized by zonation-dependent transcriptomic changes

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Homozygous factor v leiden: Two copies of the factor v gene

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Common types of MC4R dysfunction Many variants (e.g., Ser127Leu) exhibit multiple concurrent functional defects, and the majority follow a dominant inheritance pattern consistent with haploinsufficiency [29]

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