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229 A recent study also found that that glucagons ability to induce insulin secretion was reduced in isolated islets from GLP-1R knockout mice, and in wild-type mice a GLP-1R antagonist significantly reduced glucagon-induced insulin secretion

Certain health conditions that affect the gut, like Crohns or celiac disease, can also make absorption a major challenge

These medications act on the body's ability to regulate appetite, glucose, insulin, and digestion, and those systems don't function identically from person to person