how to reduce side effects of glp 1 GLP-1 Therapy Part 2: Preventing and Managing – Sarah Hormachea GLP-1 Agonists: Using Semaglutide, Tirzepatide,

The term describes the visible facial aging that can accompany rapid, significant weight loss, characterized by: Hollowed, sunken cheeks where fullness once existed Prominent nasolabial folds (lines from nose to mouth corners) that deepen dramatically Jowl formation or worsening along the jawline Under-eye hollows and dark circles that create a tired appearance Temple hollowing that creates a gaunt, skeletal look Marionette lines extending from mouth corners downward Loose, sagging skin especially around the neck and lower face Increased wrinkles and crepiness from loss of skin elasticity According to a 2025 systematic review published in Plastic and Reconstructive Surgery , Ozempic face describes exaggerated volume loss from semaglutide therapy, resulting in advanced facial aging that has led to a measurable increase in facial restoration procedures Daneshgaran et al., 2025

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LC and ALC also affect the hypothalamic-pituitary-gonadal (HPG) axis, inducing secretion of reproductive hormones [83, 85, 86]

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