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CXCR3, CXCR4, and CXCR5 enhance Th1 cells, lymphocytes, B cells, and T follicular helper (Tfh) cells into joint, respectively (100, 103)

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Structural: Collagen, elastin, glycosaminoglycan synthesis Dermal: Fibroblast proliferation, ECM remodeling, skin repair Vascular: Angiogenesis, wound closure, blood vessel formation Systemic: Gene expression modulation, antioxidant defense, anti-inflammatory pathways Together, these findings suggest experimental utility for GHK-Cu across multiple biological systems