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Retatrutide also reduced pain in patients with knee osteoarthritis, with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores dropping by as much as 4.5 points, a 75.8% reduction with the 9 mg dose, compared with a 2.4 point (40.3%) reduction for placebo

The medication has been structurally modified to resist breakdown by the enzyme dipeptidyl peptidase-4 (DPP-4), which allows it to remain active in the body for an extended period

Before injecting Wegovy for the first time, talk with your doctor or pharmacist

Most insurance companies will authorize an early refill for medications damaged during shipping, but you may need to provide documentation including photos, tracking information, and a statement from your pharmacy confirming the temperature excursion