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Netrin-1, acting via its receptor DCC, has been shown to drive the sprouting of calcitonin gene-related peptide (CGRP)+ nociceptive fibers in the subchondral bone, thereby contributing directly to pain hypersensitivity associated with OA (Zhu et al., 2019)

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For example, Novo Nordisk's CagriSema, a combination of semaglutide and cagrilintide, has shown superior results in lowering blood sugar and promoting weight loss compared to semaglutide alone

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Urueta Portillo D., Mazo-Canola M., Alhaj S