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[15] Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects

However, this therapeutic approach also brings side effects, such as -cell hyperplasia and hyperglucagonemia, and the mechanisms underlying these side effects remain elusive

A glucose load (2 g/kg body weight) was given to each rat orally with a feeding syringe

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