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Thus, they may have a different effect on the activity of the HPA axis in humans

These symptoms are primarily due to the mode of action of GLP-1 RAs on the gut, as a GLP-1 may directly or indirectly regulate electrolyte and fluid homeostasis by influencing feeding and drinking behavior as well as electrolyte transport in the kidneys and gastrointestinal tract [25]

What concerns clinical experts like Bayat is that patients, driven by societal pressure and social media trends, are bypassing the vital safeguards built into South Africas medical infrastructure

Its also the target of popular weight loss medications like Ozempic and Wegovy