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These nonseroconverters include people on B-cell-depleting therapy or people with inborn errors of immunity, as these individuals are typically more susceptible to prolonged infection and higher rates of progression to severe disease [36, 37]

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34 Specifically, HE patients were found to have a lower prevalence of short-chain fatty acid (SCFA)-producing families, such as Lachnospiraceae and Ruminococcaceae , and increased prevalence of potentially pathogenic Enterobacteriaceae