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Conversely, Ubx N51A co-expressed with Ubx WT promoted the retention of cassette exons of Ubx-target genes regulated exclusively at the splicing level (while their expression remained unchanged)

Figure 1 In the following text, we considered these questions in more detail

12 Cellular swelling, karyolysis, karyorrhexis, vacuolization, inflammation and release of cellular contents (alanine aminotransferase, ALT) are key processes of hepatocyte necrosis and related death in humans, as shown by the biochemical evidence of severe elevations in aminotransferases, especially ALT

This review focuses on three key areas: Safety: Is there enough evidence to support safe use