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A larger amount of L-carnitine is needed for this function, since acetyl-CoA either needs to be metabolized by the TCA cycle or exported with the use of L-carnitine in form of acetyl-carnitine

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8 weeks) significantly improves elevated blood urine nitrogen, serum creatinine, and urinary albumin excretion rate and alleviates renal hypertrophy, mesangial expansion and glomerular fibrosis in streptozocin-induced type 1 diabetic rat

In addition, carnitine can also activate glucocorticoid receptor (GR) and regulate glucocorticoid- responsive genes through this mechanism, playing a role in glucocorticoid regulation [81], and reducing glucocorticoid-induced muscle atrophy in patients with pemphigus [82]