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If it is, it is likely to become available first to those who need it most and will be subject to strict eligibility criteria

They should be considered superior in most patients, including those with HF and CKD.3 However, ischaemia prevention is superior for GLP-1 RAs, thus making them preferable in patients with predominant ASCVD risk.3 Differences in routes of administration and adverse effect profiles may also play a role in prescription decisions

The STEP program (semaglutide for weight management, The New England Journal of Medicine , 2021) anchors the weight-loss data

Healthcare providers must be vigilant in monitoring patients for signs of serotonin toxicity, especially those taking serotonergic drugs