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This receptor is expressed on pituitary somatotrophs and, when started, boosts growth hormone release through a pathway distinct from GHRH

Common side effects include nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, particularly during the initial titration phase

This comparison focuses on four compounds that define the current state of the field: semaglutide (the established benchmark), tirzepatide (the dual-agonist leader), retatrutide (the triple-agonist frontier), and orforglipron (the oral non-peptide breakthrough)

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