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NAFLD is tightly associated with the global pandemic of obesity, metabolic syndrome (MS) and T2D, as well as with several genetic factors
Additionally, the twins parents implemented a rigorous diet and nutrition intervention around the time of diagnosis
Some patients may respond better to surgery than medication, especially if they have struggled with severe obesity for years and also have metabolic complications
CLOCK and BMAL1 the positive transcriptional activators in the core circadian loop have been shown to regulate DNA damage response pathways and to interact directly with telomere-binding proteins
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