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Howard-Thompson A, Khan M, Jones M, George CM

(It should be noted that children tend to have lower levels than adults, but the laboratory did not have a pediatric reference range.) After administration of DMSA, there was little change in the average level (a small decrease, not statistically significant), but the standard deviation became dramatically smaller

Sediment or Precipitate Beyond discoloration, visible sediment or precipitate settling at the bottom of the vial is another clear sign of degradation it indicates the peptide is no longer fully dissolved in solution, which typically follows a freeze-thaw event, extended storage past the stability window, or an original reconstitution issue

In the GLP-1 RA cohort, the risk of DKA remained broadly constant, whilst the risk of DKA within the SGLT2i cohort increased with time and the difference in risk became statistically significant at year 5